The glucose ketone index: a proposed quantitative biomarker to support cancer and chronic disease prevention and management

Published in Frontiers in Science, this landmark paper proposes using the glucose ketone index (GKI) as a standardized clinical biomarker to track nutritional ketosis and metabolic health. The authors argue that monitoring the ratio of blood glucose to beta-hydroxybutyrate can help clinicians assess mitochondrial function and guide lifestyle interventions for chronic diseases. Source: https://www.frontiersin.org/journals/science/articles/10.3389/fsci.2026.1763395